RANKL Inhibition Through Osteoprotegerin Blocks Bone Loss in Experimental Periodontitis
نویسندگان
چکیده
منابع مشابه
RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis.
BACKGROUND Prevention of alveolar bone destruction is a clinical challenge in periodontal disease treatment. The receptor activator of nuclear factor-kappa B ligand (RANKL) inhibitor osteoprotegerin (OPG) inhibits osteoclastogenesis and suppresses bone resorption. METHODS To study the effects of RANKL inhibition on alveolar bone loss, an experimental ligature-induced model of periodontitis wa...
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Upon the discovery of RANK, RANKL and OPG in the late 1990s, their importance in the maintenance of the skeletal structure and their dramatic role in bone disease were largely unexpected. In recent years the understanding of these proteins, in particular their regulation, has greatly increased. This review aims to bring the interested reader up to date with the latest news and views on the mech...
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ژورنال
عنوان ژورنال: Journal of Periodontology
سال: 2007
ISSN: 0022-3492,1943-3670
DOI: 10.1902/jop.2007.070073